Unlock the Secrets of UV Exposure with Sequential's Cutting-Edge Microbiome Testing
Why Microbiome Testing for SPF Products?
According to the Skin Cancer Foundation, about 1 in 5 Americans will develop skin cancer by the age of 70, with UV exposure being one of the most common causes. With the growing awareness of the risks associated with UV damage, in vivo testing for SPF products has become increasingly crucial. The skin microbiome plays a pivotal role in protecting against UV radiation, but excessive sun exposure can disrupt this delicate balance, leading to increased risk for skin cancer and other forms of skin damage.
By conducting in vivo testing, companies can better assess how sunscreen and SPF products interact with the microbiome, ensuring not only UV protection but also the maintenance of a healthy skin barrier. This holistic approach is essential to create safer, more effective sun-care products that prevent long-term damage (American Academy of Dermatology).
Sequential is leading the way in microbiome testing for the industry. With a specialized focus on skin conditions, we have developed an innovative solution tailored to help you understand the root causes of UV exposure at the microbial level. Our proprietary sequencing panel is designed specifically to offer in-depth analysis of sun-exposed microbiota, giving you the tools to transform skincare solutions.
Customized Analysis
Tailored insights specific to UV exposure, allowing your R&D team to develop more personalized and effective products.
Actionable Data
Leverage detailed reports to guide formulation decisions and validate product efficacy with precision.
Product Innovation
New SPF products or enhancing existing lines, our data helps you create targeted solutions with proven results.
Precision Sequencing
Target specific microbial communities associated with sun exposure and UV related skin conditions.
Smart Probes™
Our dedicated team of scientists has developed an innovative method for evaluating the effects of sun exposure and UV radiation on the skin using our Smart Probes™ technology. This proprietary panel features 23 key markers that we’ve identified as having the most significant influence on skin health, particularly in response to UV damage. To further understand the impact of UV radiation on the skin’s microbiome and overall health, we utilize qPCR technology. This advanced technique allows us to accurately measure changes in microbial populations and skin health following sun exposure.
By closely analyzing how sun care products interact with these key markers and microbes, companies can develop solutions that not only protect against UV damage but also support the skin’s natural defenses, ensuring long-term skin health and resilience against sun-induced aging and other effects.
Sun/UV Panel Targets
Sphingomonas
Sphingomonas has been shown to be highly resistant to UV irradiation and capable of reducing reactive oxygen species (ROS) levels in human keratinocytes—the predominant cell type in the epidermis. This discovery underscores the important role that members of the skin microbiome, such as Sphingomonas, play in protecting human skin from solar radiation damage. By mitigating oxidative stress caused by UV exposure, Sphingomonas may contribute to healthier skin and potentially enhance the skin's natural defense mechanisms.
Harel N, Ogen-Shtern N, Reshef L, Biran D, Ron EZ, Gophna U. Skin microbiome bacteria enriched following long sun exposure can reduce oxidative damage. Res Microbiol. 2023 Nov-Dec;174(8):104138. doi: 10.1016/j.resmic.2023.104138. Epub 2023 Sep 16. PMID: 37722498.
Cyanobacteria
Cyanobacteria have shown potential in skin care due to their ability to decrease pigmentation and reduce damage associated with photoaging. According to research, Cyanobacteria on the skin surface can help mitigate these effects by lowering melanin production and protect the skin from oxidative stress, which contributes to the aging process.
Skowron K, Bauza-Kaszewska J, Kraszewska Z, Wiktorczyk-Kapischke N, Grudlewska-Buda K, Kwiecińska-Piróg J, Wałecka-Zacharska E, Radtke L, Gospodarek-Komkowska E. Human Skin Microbiome: Impact of Intrinsic and Extrinsic Factors on Skin Microbiota. Microorganisms. 2021 Mar 5;9(3):543. doi: 10.3390/microorganisms9030543. PMID: 33808031; PMCID: PMC7998121.
Malassezia furfur
Malassezia furfur is a species of yeast commonly found on human skin, often associated with various dermatological conditions. Despite its ability to synthesize a UV-protective substance called pityriacitrin, Malassezia furfur demonstrates high sensitivity to ultraviolet (UV) radiation.