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TARGETED SKIN PANEL Atopic Dermatitis Targeted Panel 23 Smart Probes ™ Atopic Dermatitis Panel Validated targets: Staphylococcus aureus, Malassezia spp, Staphylococcus epidermidis Absolute Quantification End-to-end Service Qet a Quote Atopic Dermatitis Study with Sequential's Cutting-Edge Microbiome Testing Why Microbiome Testing for Atopic Dermatitis? Atopic dermatitis (AD), a chronic inflammatory skin condition, affects around 31.6 million people in the U.S., with 15-20% of children globally and 7.3% of U.S. adults experiencing the condition (National Eczema Association). AD often results from a combination of genetic predisposition and environmental triggers, such as irritants in cosmetic products. Disruptions to the skin’s microbiome play a significant role in the disease's development and severity. Imbalances in beneficial and harmful microbes can exacerbate AD, highlighting the importance of targeted treatments. In vivo testing for products aimed at managing AD is essential because it allows researchers to understand how formulations impact both the skin barrier and microbiome in real-world conditions. Properly tested products can help reduce irritation and avoid worsening symptoms, offering a science-backed approach to skincare for those with AD. Sequential is leading the way in microbiome testing for the industry. With a specialized focus on skin conditions, we have developed an innovative solution tailored to help you understand the root causes of AD at the microbial level. Our proprietary sequencing panel is designed specifically to offer in-depth analysis of AD-associated microbiota, giving you the tools to transform skincare solutions. Customized Analysis Tailored insights specific to AD-prone skin, allowing your R&D team to develop more personalized and effective products. Actionable Data Leverage detailed reports to guide formulation decisions and validate product efficacy with precision. Product Innovation New AD treatments or enhancing existing lines, our data helps you create targeted solutions with proven results. Precision Sequencing Target specific microbial communities associated with AD development and severity. Smart Probe s ™ Our dedicated team of scientists has developed a revolutionary method for evaluating microbes through our Smart Probes™. This proprietary panel includes 23 key microbes that we have specifically identified as having the most significant impact on skin health. To further understand the intricate relationship between atopic dermatitis (AD) and the skin microbiome, we use qPCR technology. This advanced technique allows us to precisely quantify microbial populations on the skin, providing deeper insights into how AD affects the microbiome. By closely monitoring how products interact with both beneficial and harmful microbes, companies can create solutions for AD but also restore a healthy balance to the skin’s ecosystem. Atopic Dermatitis Panel Targets Staphylococcus aureus This bacterium is frequently found in higher numbers on the skin of individuals with atopic dermatitis. It can exacerbate inflammation and contribute to skin barrier disruption. Malassezia spp This genus of yeast, which is part of the normal skin flora, can become overgrown in individuals with atopic dermatitis, potentially aggravating symptoms. Staphylococcus epidermidis While generally considered a commensal organism, imbalances in its population, along with other microbes, can influence the skin's health and contribute to atopic dermatitis symptoms. Industry Leader in Absolute Quantification Sequential’s Smart Probe ™ qPCR approach to microbiome analysis can resolve species and subspecies, giving statistically significant findings between skin conditions on in vivo human samples, compared to conventional sequencing approaches. Relevant Research Answers for Atopic Dermatitis and Allergies: What is the Role of the Skin Bacteriome? Understanding Atopic Dermatitis Topical Steroid Withdrawal & the Skin Microbiome Read More Articles

Simplify your Study Protocols with our Tailored Candidate Recruitment Highlight your specific requirements for clinical test subjects and we will take care of the entire candidate recruitment process for you, whether it is in-person or remote. This allows us to closely supervise and guarantee the quality of microbiome collection. 10,000+ Subject Database We offer candidate recruitment across a diverse pool of candidates to give better insights into how certain formulations work with individuals of different backgrounds. In Lab or Remote Testing The nature of our recruitment process is often linked to at-home testing, however, if you would prefer a controlled environment to test participants, we can arrange for testing to be conducted within our labs in Singapore, London and New York City. Simplified Recruitment Process As a global company, we pride ourselves in our reach and ensuring your study targets are met. We can recruit all the candidates required by the study regardless of geographical barriers. Longitudinal Studies Understanding the long-term impact of your formulation of personal care products is only possible with our in vivo solution which requires human participants to test the products on themselves. Why is a Human Approach Better when it Comes to Personal Care Product Testing? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. in vitro Lab Testing in vivo Human Testing Analyze select bacteria within a lab setting Narrow view of microbiome: Isolated from other bacteria Cannot extract meaningful conclusions on how the product will interact with its place of application Limited analysis: brief snapshot of how the product interacts with an isolated bacteria Analyze all bacteria within its natural context Broad view of microbiome: you can see interactions between bacteria Can extract meaningful conclusions on how the product will interact with its place of application Longitudinal analysis: evaluate the product over time and its impact on the microbiome Normal to Atopic Skin It’s crucial to test your product on individuals suffering through the concerns your active ingredients are targeting. This is why we believe in a fully personalized approach to candidate recruitment and human testing, bringing forward those individuals that your products are genuinely designed to help. FAQ What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.

TARGETED SKIN PANEL Rosacea Targeted Panel 23 Smart Probes ™ Rosacea Panel Validated targets: Demodex mites, Bacillus oleronius, Helicobacter pylori Absolute Quantification End-to-end Service Qet a Quote Unlock the Secrets of Rosacea with Sequential's Cutting-Edge Microbiome Testing Why Microbiome Testing for Rosacea? Rosacea is a chronic skin condition affecting an estimated 16 million Americans and millions more worldwide, primarily adults over 30 (National Rosacea Society). Characterized by redness, visible blood vessels, and inflammation, rosacea can significantly impact an individual’s quality of life. Research suggests that the skin microbiome plays a crucial role in the development and severity of rosacea. Specifically, imbalances in microbial populations, such as an overgrowth of Demodex mites or harmful bacteria, can exacerbate symptoms. In vivo testing of skincare products for rosacea is essential to ensure that formulations are compatible with the unique microbiome of rosacea-prone skin. Such testing allows researchers to observe real-world effects on microbial balance and inflammation, ensuring that products do not unintentionally worsen symptoms. Without this careful testing, products may disrupt the microbiome further, leading to increased redness, irritation, or flare-ups. Sequential is leading the way in microbiome testing for the industry. With a specialized focus on skin conditions, we have developed an innovative solution tailored to help you understand the root causes of rosacea at the microbial level. Our proprietary sequencing panel is designed specifically to offer in-depth analysis of rosacea-associated microbiota, giving you the tools to transform skincare solutions. Customized Analysis Tailored insights specific to rosacea-prone skin, allowing your R&D team to develop more personalized and effective products. Actionable Data Leverage detailed reports to guide formulation decisions and validate product efficacy with precision. Product Innovation New rosacea treatments or enhancing existing lines, our data helps you create targeted solutions with proven results. Precision Sequencing Target specific microbial communities associated with rosacea development and severity. Smart Probe s ™ Our dedicated team of scientists has developed a revolutionary method for evaluating microbes through our Smart Probes™, a proprietary panel that includes 23 key microbes specifically identified as having the most significant impact on skin health. To further understand the complex relationship between rosacea and the skin microbiome, we utilize qPCR technology. This advanced method allows us to accurately quantify microbial populations on the skin, offering deeper insights into how rosacea affects the balance of beneficial and harmful microbes. By closely monitoring how skincare products interact with these microbes, companies can develop solutions that not only target rosacea symptoms but also help restore a healthier, balanced skin microbiome, providing long-term relief for sufferers. Rosacea Panel Targets Demodex mites (Demodex folliculorum and Demodex brevis) These tiny mites are normally present on the skin but are often found in higher numbers on the skin of individuals with rosacea. Their presence is thought to trigger inflammatory responses. Forton FMN. The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea? Dermatol Ther (Heidelb). 2020 Dec;10(6):1229-1253. doi: 10.1007/s13555-020-00458-9. Epub 2020 Oct 23. PMID: 33095403; PMCID: PMC7649190. Kim HS. Microbiota in Rosacea. Am J Clin Dermatol. 2020 Sep;21(Suppl 1):25-35. doi: 10.1007/s40257-020-00546-8. PMID: 32914214; PMCID: PMC7584533. Bacillus oleronius This bacterium has been linked to rosacea, particularly in relation to the inflammatory response associated with the condition. It is often found in higher quantities on the skin of rosacea patients. Helicobacter pylori Although not a skin microbe per se, this bacterium, commonly associated with gastrointestinal issues, has been implicated in some studies as a potential contributor to rosacea flare-ups or exacerbations. Yang X. Relationship between Helicobacter pylori and Rosacea: review and discussion. BMC Infect Dis. 2018 Jul 11;18(1):318. doi: 10.1186/s12879-018-3232-4. PMID: 29996790; PMCID: PMC6042414. Industry Leader in Absolute Quantification Sequential’s Smart Probe ™ qPCR approach to microbiome analysis can resolve species and subspecies, giving statistically significant findings between skin conditions on in vivo human samples, compared to conventional sequencing approaches. Relevant Research How Does the Skin Microbiome Influence Rosacea? Unveiling the Microbial Puzzle Read More Articles

Cookie Policy Last updated: 13 March 2024 Sequential Skin Ltd ("us", "we", or "our") operates the www.sequential.bio website (the "Service"). This page informs you of our policies regarding the collection, use, and disclosure of personal data when you use our Service and the choices you have associated with that data. We use your data to provide and improve the Service. By using the Service, you agree to the collection and use of information in accordance with this policy. Unless otherwise defined in this Cookie Policy, the terms used in this Cookie Policy have the same meanings as in our Privacy Policy. Definitions Service: Service is the www.sequential.bio website operated by Sequential. Personal Data: Personal Data means data about a living individual who can be identified from those data (or from those and other information either in our possession or likely to come into our possession). Usage Data: Usage Data is data collected automatically either generated by the use of the Service or from the Service infrastructure itself (for example, the duration of a page visit). Cookies: Cookies are small pieces of data stored on your device (computer or mobile device). Data Controller: Data Controller means the natural or legal person who (either alone or jointly or in common with other persons) determines the purposes for which and the manner in which any personal information are, or are to be, processed. For the purpose of this Privacy Policy, we are a Data Controller of your Personal Data. Data Processors (or Service Providers): Data Processor (or Service Provider) means any natural or legal person who processes the data on behalf of the Data Controller. We may use the services of various Service Providers in order to process your data more effectively. Data Subject (or User): Data Subject is any living individual who is using our Service and is the subject of Personal Data. Information Collection and Use We use cookies and similar tracking technologies to track the activity on our Service and hold certain information. Types of Cookies We Use Session Cookies: We use Session Cookies to operate our Service. Preference Cookies: We use Preference Cookies to remember your preferences and various settings. Security Cookies: We use Security Cookies for security purposes. Advertising Cookies: Advertising Cookies are used to serve you with advertisements that may be relevant to you and your interests. Use of Data We use the collected data for various purposes: To provide and maintain our Service To notify you about changes to our Service To allow you to participate in interactive features of our Service when you choose to do so To provide customer support To gather analysis or valuable information so that we can improve our Service To monitor the usage of our Service To detect, prevent and address technical issues Retention of Data We will retain your Personal Data only for as long as is necessary for the purposes set out in this Cookie Policy. We will retain and use your Personal Data to the extent necessary to comply with our legal obligations (for example, if we are required to retain your data to comply with applicable laws), resolve disputes, and enforce our legal agreements and policies. Your Choices Regarding Cookies If you'd like to delete cookies or instruct your web browser to delete or refuse cookies, please visit the help pages of your web browser. Please note, however, that if you delete cookies or refuse to accept them, you might not be able to use all of the features we offer, you may not be able to store your preferences, and some of our pages might not display properly. Service Providers We may employ third party companies and individuals to facilitate our Service ("Service Providers"), provide the Service on our behalf, perform Service-related services, or assist us in analyzing how our Service is used. These third parties have access to your Personal Data only to perform these tasks on our behalf and are obligated not to disclose or use it for any other purpose. Changes to This Cookie Policy We may update our Cookie Policy from time to time. We will notify you of any changes by posting the new Cookie Policy on this page. You are advised to review this Cookie Policy periodically for any changes. Changes to this Cookie Policy are effective when they are posted on this page. Contact Us If you have any questions about this Cookie Policy, please contact us: By email: team@sequential.bio By visiting this page on our website: www.sequential.bio

Create Your Next Best-Selling Formulation A well-designed formulation takes into account the diverse and delicate ecosystem of the microbiome. By incorporating ingredients that promote a harmonious relationship with the microbiota, such as prebiotics and postbiotics, a product can positively impact the microbial diversity and balance on the body. Having collected over 20,000+ human skin microbiome samples through in vivo clinical research, we can help you take your product from conception to completion. Consultation Book a consultation to start creating your microbiome supporting formulation. Whether you need help starting out or are already in the midst of your process, we can support you. INCI List Examination Have an INCI list and are unsure if it will be a formula? No need to look further, we will gladly look through your proposed INCI list and revert back with feedback. Co-Develop Let us be your Chief Science Officer, or your scientific advisory, and leverage our dataset for the co-development of products that suit your demographic and application. SKINCARE FORMULATIONS Regular to Atopic Skin, Start Formulating Today! What Contributes to a Microbiome Supporting Formulation? When creating a product that "maintains the microbiome", it is crucial to understand that every ingredient used is important. Hero ingredient-led philosophy cannot be applied in the formulation process as it is the blend of each ingredient that will create a product to support and improve the balance of the skin microbiome. Fermented ingredients (postbiotics) and those that act as food for microbes (prebiotics) are also known to have a positive impact on formulations when paired with the right preservative systems, surfactants, emollients, etc. It is still rare to find live bacteria (probiotics) in formulations, however, if encapsulated correctly, it could show improvement in the microbiome balance. Prebiotics Prebiotics beneficially affect the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria on the skin, and thus improves host health. Prebiotics act as food for the microbes on the skin, and allow good bacteria to grow and thrive. Probiotics Probiotics are living microorganisms that confer benefit to the host when applied to the body. Because probiotics are live bacteria, it is incredibly difficult to preserve and put into skincare products (especially when skincare contains preservatives). In fact, some products on the market that say they use probiotics, are actually using prebiotics or postbiotics. Postbiotics Postbiotics are the byproduct of fermented live bacteria (probiotics) or inactivated microorganisms. The process of fermentation releases nutrients inside of the bacteria and holds concentrated and nourishing skin health benefits that help to balance the skin microbiome. INGREDIENTS FROM MICROBIAL ORIGIN No INTENDED TO BE UTILISED BY THE HUMAN MICROBIOTA? No Yes Yes ARE THEY VIABLE? No Yes ORIGIN VIABILITY FUNCTION ORDINARY INGREDIENT ORDINARY INGREDIENT WITH PREBIOTIC FUNCTION INTENDED TO BE UTILISED BY THE HUMAN MICROBIOTA? PROBIOTIC INGREDIENT No POSTBIOTIC INGREDIENT Yes POSTBIOTIC INGREDIENT WITH PREBIOTIC FUNCTION Our Leading Expert & Skincare Director Pétronille Houdart A pharmacist by training, Pétronille specialized in dermo pharmacy and cosmetology. She has garnered extensive experience in the formulation of cosmetic products and is passionate about skincare. She started her career working for a private-label contract manufacturer that focused on custom cosmetic formulations for clients ranging from big brands to private dermatologist products. She has previously created a high-performance customisable formulation brand and is vocal about bespoke and innovative cosmetic formulations. Request a Consultation Ashfi Rahman, Co-founder at HonestStory "Sequential gave us completely essential consulting work on microbiome skincare formulations. They are the only company out there that combines their knowledge of microbiome testing with formulation expertise, and we're very happy to be working with them to develop the first microbiome skincare in India." FAQ What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations.

Unveiling Sequential Bio’s New London Lab testing HQ 18th October 2022 - In an effort to keeping the entire testing process in-house, allowing for rigorous quality control, and meeting the demand of our European clients - today we announce the opening of our testing lab in London. Sequential is proud to announce that it will open a European HQ, and testing lab site in White City, London. One key quality that makes Sequential stand out from its competitors is keeping the testing protocols and quantitative analysis in-house. This gives them the ability to ensure the processing, and targeting of microbiome markers for their clients is extremely high quality. “Innovative R&D, and rigorous quality control on our lab testing and processes have always been front of mind at Sequential. By opening a lab in London, we’re responding to the demand from customers - whilst retaining control over our quality in testing.” - Dr Oliver Worsley, CEO/Co-Founder. Adding to their testing labs in Singapore, and New York, in which they serve Singapore, Thailand, Australia, and the US markets. This enables faster turnaround time for European clients, as the demand for non-invasive molecular analysis of the skin reaches new heights in Europe. Between 2018 - 2022, there have been over 34 microbiome deals (licensing and investments) made. With an average contract value of $257M, this has created over $2.3B of value in the gut and skin microbiome space. Europe is a significant player in the global microbiome field, expected to grow at a CAGR of 24.25% (between 2022-2028). About Sequential Sequential is part of the Sequential Skin group – with a US lab in New York City, alongside a lab in London and a lab in Singapore. Sequential Bio team has over 20 years of combined expertise in genetics, epigenetics, and microbiome research. It was recognised recently as the “Most Significant ” Testing Method in the Industry. Sequential has validated its AI-driven testing platform with over 30 companies, analyzing over 12,000 skin microbiome samples. They specialise in skin, scalp and vulva/vaginal microbiome samples. They are supported by Enterprise SG, A*STAR, Genome Institute of Singapore, IndieBio New York, SOSV, Metaplanet Holdings, Scrum Ventures, Genedant VC, Ben Holmes (ex. General Partner at Index Ventures), Innovate UK, and are a resident company of Johnson & Johnson Innovation – JLABS.

Search Results All (70) Research Articles (42) Other Pages (28) 70 items found Research Articles (42) Wound Wonders: Innovation in the Microbiome Space for Burn Healing In the UK, around 120,000 people visit A&E annually due to burn injuries, with 72% resulting in hypertrophic scarring, a type of raised scar that forms within the boundaries of the original wound due to excessive collagen production during healing. While traditional wound dressings effectively promote healing, there’s growing interest in innovative approaches that address post-burn scarring more effectively. What We Know: Traditional dressings help close and heal wounds by providing hydration and antimicrobial protection, but they aren’t designed to prevent or treat post-burn scarring. Burns disrupt the skin’s microbial balance, favouring heat-loving microbes like Aeribacillus, Caldalkalibacillus and Nesterenkonia while reducing beneficial bacteria such as Cutibacterium, Staphylococci and Corynebacteria . Increased levels of Corynebacterium are linked to higher infection risks, whereas Staphylococci and Cutibacterium are associated with lower infection rates post-burn (Yang et al., 2024). Despite reduced bacterial richness at the genus level, burn patients exhibit increased microbial community diversity and evenness. This altered microbial landscape, marked by a lower overall bacterial burden and an overgrowth of Staphylococcus species, highlights a persistent dysbiotic state in the skin microbiota during the subacute phase of wound healing (Liu et al., 2018) . Industry Impact and Potential: @Healome Therapeutics has developed a groundbreaking bioactive skin dressing technology, recently cleared by the @Medicines and Healthcare products Regulatory Agency (MHRA) for a phase I trial aimed at reducing scarring. The trial, conducted at Queen Elizabeth Hospital in Birmingham, UK, involves 25 patients with burns covering 3-20% of their body surface. Healome’s innovative dressing is a clear film that not only offers the benefits of traditional wound dressings but also incorporates synthetic human-derived decorin protein, which plays a critical role in wound healing. This protein reduces the inflammatory response and regulates the wound’s microenvironment. Early research suggests that this approach may reduce fibrosis and promote tissue regeneration, offering new hope for scar management in burn patients. Products like Healome’s dressing showcase the exciting potential of using the microbiome and skin environment to enhance wound healing, paving the way for future innovations in burn care. Our Solution: At Sequential, we offer comprehensive services for evaluating product impacts and formulations, supported by a vast database of over 20,000 microbiome samples and 4,000 ingredients, along with a global network of more than 10,000 testing participants. Our customizable microbiome studies simulate real-world testing scenarios, ensuring that your products preserve biome integrity while delivering optimal results. References: Liu, S.-H., Huang, Y.-C., Chen, L.Y., Yu, S.-C., Yu, H.-Y. & Chuang, S.-S. (2018) The skin microbiome of wound scars and unaffected skin in patients with moderate to severe burns in the subacute phase. Wound Repair and Regeneration: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 26 (2), 182–191. doi:10.1111/wrr.12632. Yang, Y., Huang, J., Zeng, A., Long, X., Yu, N. & Wang, X. (2024) The role of the skin microbiome in wound healing. Burns & Trauma. 12, tkad059. doi:10.1093/burnst/tkad059. Is Swimming Wrecking Your Skin Microbiome? Swimming is a widely enjoyed physical activity that provides various health benefits, such as improved cardiovascular fitness, enhanced muscle strength, and reduced stress levels. Nevertheless, swimming also involves exposure to different water environments, including chlorinated pools, seawater, and freshwater lakes. Each of these environments possesses distinct chemical and microbial properties that can uniquely affect the skin microbiome. Consequently, comprehending the significance of the skin microbiome in swimming is essential. What we know: Studies have found that exposure to chlorinated pool water reduces microbial diversity on the skin, as it acts as a disinfectant, killing both harmful and beneficial bacteria, which can lead to an imbalance in the skin microbiome. This imbalance may increase the risk of skin conditions like dermatitis and infections (Puce et al ., 2022). Ocean water contains a diverse range of marine bacteria, thereby enhancing the diversity of the skin microbiome. The ocean water simultaneously removes resident skin bacteria while depositing ocean-borne bacteria onto the skin (Nielsen et al ., 2019). The predominating phyla Actinobacteria , Firmicutes , and Proteobacteria on the skin changed after swimming when compared to before swimming tends to decrease, whereas Bacteroidetes tends to increase. As time passed, the bacterial community composition trended towards baseline (Nielsen et al ., 2019). The quantity of Vibrio spp. found on human skin was over ten times higher than that in the ocean water sample (which was only 0.032%), indicating that Vibrio spp. has a particular affinity for adhering to human skin (Nielsen et al ., 2019). Industry impact & potential: Research shows that males are more prone to acquiring infections from Vibrio vulnificus and Aeromonas spp. following water exposure. Future research could provide valuable insights into the factors contributing to these infections and explore potential differences in the skin microbiome between males and females after such exposure (Nielsen et al ., 2019). Formulations such as post and pre-swim cleansers and moisturizers should be designed to aid in microbiome recovery while also protecting the skin from chlorine and salt damage. Our solution: Sequential, is a company focusing on microbiome studies. We carry out various services from clinical testing to helping with formulations. We have at home testing kits that will allow you to discover the state of your skin microbiome. Through our Skin Health Tracker app, we can give you tips on how you can improve your skin and the microbiome. Reference: Nielsen MC, Jiang SC. Alterations of the human skin microbiome after ocean water exposure. Mar Pollut Bull. 2019 Aug;145:595-603. doi: 10.1016/j.marpolbul.2019.06.047. Epub 2019 Jul 2. PMID: 31590829; PMCID: PMC8061468. Puce L, Hampton-Marcell J, Trabelsi K, Ammar A, Chtourou H, Boulares A, Marinelli L, Mori L, Cotellessa F, Currà A, Trompetto C, Bragazzi NL. Swimming and the human microbiome at the intersection of sports, clinical, and environmental sciences: A scoping review of the literature. Front Microbiol. 2022 Aug 3;13:984867. doi: 10.3389/fmicb.2022.984867. PMID: 35992695; PMCID: PMC9382026. Exploring the Impact of The Scalp Microbiome on Alopecia Treatments: New Insights and Innovations The scalp microbiome plays a crucial yet often overlooked role in the development and treatment of alopecia. Studies have shed light on how rebalancing these microbes can significantly enhance the efficacy of treatments for hair loss, offering new hope for patients. What We Know: Cutibacterium spp. and Staphylococcus spp . constitute about 90% of healthy scalp microbiomes, with Corynebacterium spp., Streptococcus spp., Acinetobacter spp . and Prevotella spp . making up the remaining 10% (Jo et al., 2022) . Alopecia patients’ scalp microbiomes exhibit increased C. acnes , Stenotrophomonas geniculata, Wallemia and Eurotium , as well as reduced Malassezia, when compared to healthy individuals. Therefore, it is likely that an imbalance in scalp microbiota may contribute to alopecia (Zhang et al., 2024) . Industry Impact and Potential: Platelet-rich plasma (PRP) has proven effective in treating alopecia, but its impact on the scalp microbiome was previously unexplored. A recent study revealed that PRP treatment rebalances the scalp microbiome, specifically increasing Cutibacterium levels while decreasing Staphylococcus and Lawsonella levels (Zhang et al., 2024) . Cutibacterium plays a vital role in maintaining skin homeostasis and is crucial for lipid regulation, follicular niche competition, immune regulation and mitigating oxidative stress. Furthermore, the balance between Cutibacterium and Staphylococcus is important for regulating immune response. Reduction in Lawsonella suggests decreased scalp sebum production following treatment. This is relevant to alopecia treatment, as imbalances in sebum production can exacerbate hair loss by contributing to inflammation and follicle damage (Zhang et al., 2024) . Lactic acid bacteria (LAB), Limosilactobacillus fermentum LM1020 and its heat-treated version HT-LM1020, can help promote hair growth on human scalp tissue and dermal papilla cells. These bacteria work with other ingredients to fight hair loss by boosting cell growth and regulating the expression of proteins important for cell division (Bae et al., 2024) . AMOREPACIFIC patented a composition that uses extracellular follicles derived from LAB to prevent hair loss, stimulate hair growth and support overall hair health. These extracellular follicles (cellular components or secretions released by the bacteria) represent a promising advancement in alopecia treatment, offering potential benefits for both hair and scalp health. Our Solution: With a database of over 20,000 microbiome samples and 4,000 ingredients, and a global network of more than 10,000 testing participants, Sequential offers comprehensive services to evaluate product impacts and formulations. Our customisable microbiome studies provide real-life context testing, and our formulation support ensures products maintain biome integrity, making us the ideal partner for your product development and efficacy needs. References: Bae, W.-Y., Jung, W.-H., Shin, S.L., Kim, T.-R., Sohn, M., Suk, J., Jung, I., Lee, Y.I. & Lee, J.H. (2024) Heat-treated Limosilactobacillus fermentum LM1020 with menthol, salicylic acid, and panthenol promotes hair growth and regulates hair scalp microbiome balance in androgenetic alopecia: A double-blind, randomized and placebo-controlled clinical trial. Journal of Cosmetic Dermatology . n/a (n/a). doi:10.1111/jocd.16357. Jo, H., Kim, S.Y., Kang, B.H., Baek, C., Kwon, J.E., Jeang, J.W., Heo, Y.M., Kim, H.-B., Heo, C.Y., Kang, S.M., Shin, B.H., Nam, D.Y., Lee, Y.-G., Kang, S.C. & Lee, D.-G. (2022) Staphylococcus epidermidis Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss. Molecules . 27 (16). doi:10.3390/molecules27165136. Zhang, Q., Wang, Y., Ran, C., Zhou, Y., Zhao, Z., Xu, T., Hou, H. & Lu, Y. (2024) Characterization of distinct microbiota associated with androgenetic alopecia patients treated and untreated with platelet‐rich plasma (PRP). Animal Models and Experimental Medicine . 7 (2), 106–113. doi:10.1002/ame2.12414. View All Other Pages (28) Search Results | Sequential Search Results All (70) Research Articles (42) Other Pages (28) 70 items found Research Articles (42) Wound Wonders: Innovation in the Microbiome Space for Burn Healing In the UK, around 120,000 people visit A&E annually due to burn injuries, with 72% resulting in hypertrophic scarring, a type of raised scar that forms within the boundaries of the original wound due to excessive collagen production during healing. While traditional wound dressings effectively promote healing, there’s growing interest in innovative approaches that address post-burn scarring more effectively. What We Know: Traditional dressings help close and heal wounds by providing hydration and antimicrobial protection, but they aren’t designed to prevent or treat post-burn scarring. Burns disrupt the skin’s microbial balance, favouring heat-loving microbes like Aeribacillus, Caldalkalibacillus and Nesterenkonia while reducing beneficial bacteria such as Cutibacterium, Staphylococci and Corynebacteria . Increased levels of Corynebacterium are linked to higher infection risks, whereas Staphylococci and Cutibacterium are associated with lower infection rates post-burn (Yang et al., 2024). Despite reduced bacterial richness at the genus level, burn patients exhibit increased microbial community diversity and evenness. This altered microbial landscape, marked by a lower overall bacterial burden and an overgrowth of Staphylococcus species, highlights a persistent dysbiotic state in the skin microbiota during the subacute phase of wound healing (Liu et al., 2018) . Industry Impact and Potential: @Healome Therapeutics has developed a groundbreaking bioactive skin dressing technology, recently cleared by the @Medicines and Healthcare products Regulatory Agency (MHRA) for a phase I trial aimed at reducing scarring. The trial, conducted at Queen Elizabeth Hospital in Birmingham, UK, involves 25 patients with burns covering 3-20% of their body surface. Healome’s innovative dressing is a clear film that not only offers the benefits of traditional wound dressings but also incorporates synthetic human-derived decorin protein, which plays a critical role in wound healing. This protein reduces the inflammatory response and regulates the wound’s microenvironment. Early research suggests that this approach may reduce fibrosis and promote tissue regeneration, offering new hope for scar management in burn patients. Products like Healome’s dressing showcase the exciting potential of using the microbiome and skin environment to enhance wound healing, paving the way for future innovations in burn care. Our Solution: At Sequential, we offer comprehensive services for evaluating product impacts and formulations, supported by a vast database of over 20,000 microbiome samples and 4,000 ingredients, along with a global network of more than 10,000 testing participants. Our customizable microbiome studies simulate real-world testing scenarios, ensuring that your products preserve biome integrity while delivering optimal results. References: Liu, S.-H., Huang, Y.-C., Chen, L.Y., Yu, S.-C., Yu, H.-Y. & Chuang, S.-S. (2018) The skin microbiome of wound scars and unaffected skin in patients with moderate to severe burns in the subacute phase. Wound Repair and Regeneration: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 26 (2), 182–191. doi:10.1111/wrr.12632. Yang, Y., Huang, J., Zeng, A., Long, X., Yu, N. & Wang, X. (2024) The role of the skin microbiome in wound healing. Burns & Trauma. 12, tkad059. doi:10.1093/burnst/tkad059. Is Swimming Wrecking Your Skin Microbiome? Swimming is a widely enjoyed physical activity that provides various health benefits, such as improved cardiovascular fitness, enhanced muscle strength, and reduced stress levels. Nevertheless, swimming also involves exposure to different water environments, including chlorinated pools, seawater, and freshwater lakes. Each of these environments possesses distinct chemical and microbial properties that can uniquely affect the skin microbiome. Consequently, comprehending the significance of the skin microbiome in swimming is essential. What we know: Studies have found that exposure to chlorinated pool water reduces microbial diversity on the skin, as it acts as a disinfectant, killing both harmful and beneficial bacteria, which can lead to an imbalance in the skin microbiome. This imbalance may increase the risk of skin conditions like dermatitis and infections (Puce et al ., 2022). Ocean water contains a diverse range of marine bacteria, thereby enhancing the diversity of the skin microbiome. The ocean water simultaneously removes resident skin bacteria while depositing ocean-borne bacteria onto the skin (Nielsen et al ., 2019). The predominating phyla Actinobacteria , Firmicutes , and Proteobacteria on the skin changed after swimming when compared to before swimming tends to decrease, whereas Bacteroidetes tends to increase. As time passed, the bacterial community composition trended towards baseline (Nielsen et al ., 2019). The quantity of Vibrio spp. found on human skin was over ten times higher than that in the ocean water sample (which was only 0.032%), indicating that Vibrio spp. has a particular affinity for adhering to human skin (Nielsen et al ., 2019). Industry impact & potential: Research shows that males are more prone to acquiring infections from Vibrio vulnificus and Aeromonas spp. following water exposure. Future research could provide valuable insights into the factors contributing to these infections and explore potential differences in the skin microbiome between males and females after such exposure (Nielsen et al ., 2019). Formulations such as post and pre-swim cleansers and moisturizers should be designed to aid in microbiome recovery while also protecting the skin from chlorine and salt damage. Our solution: Sequential, is a company focusing on microbiome studies. We carry out various services from clinical testing to helping with formulations. We have at home testing kits that will allow you to discover the state of your skin microbiome. Through our Skin Health Tracker app, we can give you tips on how you can improve your skin and the microbiome. Reference: Nielsen MC, Jiang SC. Alterations of the human skin microbiome after ocean water exposure. Mar Pollut Bull. 2019 Aug;145:595-603. doi: 10.1016/j.marpolbul.2019.06.047. Epub 2019 Jul 2. PMID: 31590829; PMCID: PMC8061468. Puce L, Hampton-Marcell J, Trabelsi K, Ammar A, Chtourou H, Boulares A, Marinelli L, Mori L, Cotellessa F, Currà A, Trompetto C, Bragazzi NL. Swimming and the human microbiome at the intersection of sports, clinical, and environmental sciences: A scoping review of the literature. Front Microbiol. 2022 Aug 3;13:984867. doi: 10.3389/fmicb.2022.984867. PMID: 35992695; PMCID: PMC9382026. Exploring the Impact of The Scalp Microbiome on Alopecia Treatments: New Insights and Innovations The scalp microbiome plays a crucial yet often overlooked role in the development and treatment of alopecia. Studies have shed light on how rebalancing these microbes can significantly enhance the efficacy of treatments for hair loss, offering new hope for patients. What We Know: Cutibacterium spp. and Staphylococcus spp . constitute about 90% of healthy scalp microbiomes, with Corynebacterium spp., Streptococcus spp., Acinetobacter spp . and Prevotella spp . making up the remaining 10% (Jo et al., 2022) . Alopecia patients’ scalp microbiomes exhibit increased C. acnes , Stenotrophomonas geniculata, Wallemia and Eurotium , as well as reduced Malassezia, when compared to healthy individuals. Therefore, it is likely that an imbalance in scalp microbiota may contribute to alopecia (Zhang et al., 2024) . Industry Impact and Potential: Platelet-rich plasma (PRP) has proven effective in treating alopecia, but its impact on the scalp microbiome was previously unexplored. A recent study revealed that PRP treatment rebalances the scalp microbiome, specifically increasing Cutibacterium levels while decreasing Staphylococcus and Lawsonella levels (Zhang et al., 2024) . Cutibacterium plays a vital role in maintaining skin homeostasis and is crucial for lipid regulation, follicular niche competition, immune regulation and mitigating oxidative stress. Furthermore, the balance between Cutibacterium and Staphylococcus is important for regulating immune response. Reduction in Lawsonella suggests decreased scalp sebum production following treatment. This is relevant to alopecia treatment, as imbalances in sebum production can exacerbate hair loss by contributing to inflammation and follicle damage (Zhang et al., 2024) . Lactic acid bacteria (LAB), Limosilactobacillus fermentum LM1020 and its heat-treated version HT-LM1020, can help promote hair growth on human scalp tissue and dermal papilla cells. These bacteria work with other ingredients to fight hair loss by boosting cell growth and regulating the expression of proteins important for cell division (Bae et al., 2024) . AMOREPACIFIC patented a composition that uses extracellular follicles derived from LAB to prevent hair loss, stimulate hair growth and support overall hair health. These extracellular follicles (cellular components or secretions released by the bacteria) represent a promising advancement in alopecia treatment, offering potential benefits for both hair and scalp health. Our Solution: With a database of over 20,000 microbiome samples and 4,000 ingredients, and a global network of more than 10,000 testing participants, Sequential offers comprehensive services to evaluate product impacts and formulations. Our customisable microbiome studies provide real-life context testing, and our formulation support ensures products maintain biome integrity, making us the ideal partner for your product development and efficacy needs. References: Bae, W.-Y., Jung, W.-H., Shin, S.L., Kim, T.-R., Sohn, M., Suk, J., Jung, I., Lee, Y.I. & Lee, J.H. (2024) Heat-treated Limosilactobacillus fermentum LM1020 with menthol, salicylic acid, and panthenol promotes hair growth and regulates hair scalp microbiome balance in androgenetic alopecia: A double-blind, randomized and placebo-controlled clinical trial. Journal of Cosmetic Dermatology . n/a (n/a). doi:10.1111/jocd.16357. Jo, H., Kim, S.Y., Kang, B.H., Baek, C., Kwon, J.E., Jeang, J.W., Heo, Y.M., Kim, H.-B., Heo, C.Y., Kang, S.M., Shin, B.H., Nam, D.Y., Lee, Y.-G., Kang, S.C. & Lee, D.-G. (2022) Staphylococcus epidermidis Cicaria, a Novel Strain Derived from the Human Microbiome, and Its Efficacy as a Treatment for Hair Loss. Molecules . 27 (16). doi:10.3390/molecules27165136. Zhang, Q., Wang, Y., Ran, C., Zhou, Y., Zhao, Z., Xu, T., Hou, H. & Lu, Y. (2024) Characterization of distinct microbiota associated with androgenetic alopecia patients treated and untreated with platelet‐rich plasma (PRP). Animal Models and Experimental Medicine . 7 (2), 106–113. doi:10.1002/ame2.12414. View All Other Pages (28) Sequential Alle Awards | Sequential Allē Award: Sequential Wins Prestigious “Most Significant” Testing Method After being listed as a finalist as best ‘Claims testing methods & tools’ alongside Evonik, and XCellR8 - Sequential brings home top prize in C&T’s Allē Awards, 2022. ​ The personal care and cosmetics industry in the US is valued at $190B. In the context of the skin microbiome, the industry is still a relatively nascent field. However, its projected growth is significant, estimated to grow at a compounded annual growth of 29.2% between 2022-2028. Owed to the impact of products on the skin microbiome, consumer awareness, and understanding that our microbiome is intimately linked to our health. ​ Sequential is the B2B microbiome testing arm for Sequential Skin Ltd, which has developed the world’s first end-to-end platform for companies to evaluate their products on the microbiome in vivo. They specialize in skin, scalp and intimate area microbiome. ​ "Of all the 'microbiome friendly' methodologies working to address both consumer and industry concerns about the impact of cosmetics on the microbiome, this is, in my opinion, the most quantitative and promising of the lot." – C&T's Allē Award judges, 2022. ​ The company has developed a proprietary non-invasive method for collecting skin samples to analyze the skin microbiome using next-generation sequencing (NGS), with species and strain identification, in longitudinal (and clinical) studies. Services include data interpretation and the results are reported in a comprehensive, yet understandable format, ready for formulators and research scientists to incorporate into their product development pipeline. ​ “The Allē Award gives us strong confidence in the testing platform and capabilities we’ve built in Sequential. Being the first to develop an in vivo microbiome test for the industry, we’re proud to see our hard work paying off” — Petronille Houdart, DPharm, skincare director at Sequential. ​ ​ About Sequential ​ Sequential is part of the Sequential Skin group – with a US lab in New York City, alongside a lab in London and a lab in Singapore. Sequential team has over 20 years of combined expertise in genetics, epigenetics, and microbiome research. ​ Sequential has validated its AI-driven testing platform with over 30 companies, analyzing over 12,000 skin microbiome samples. They specialise in skin, scalp and vulva/vaginal microbiome samples. They are supported by Enterprise SG, A*STAR, Genome Institute of Singapore, IndieBio New York, SOSV, Metaplanet Holdings, Scrum Ventures, Genedant VC, Ben Holmes (ex. General Partner at Index Ventures), Innovate UK, and are a resident company of Johnson & Johnson Innovation – JLABS. Scalp Microbiome Testing | Sequential Scalp Microbiome Testing As the scalp care industry grows, consumers demand transparency from the brands formulating their products. It has become essential for formulators to create products they are willing to test to present scientifically backed data-driven evidence of their products' true effects. Sequential offers microbiome testing for your scalp care formulations, ranging from scalp serums, shampoos, conditioners, oils, etc. We are dedicated to understanding how your product interacts with the scalp and its microbes. Depending on how in-depth you want to go, we offer qPCR, 16S, ITS, and Shotgun Metagenomics. Download Case Study! Personalized Approach to Testing Unlike other methodologies present within the industry, Sequential's approach ensures that your product's data and analysis will stand the test of industry regulations when they are introduced. You can tailor your study entirely to your unique requirements. Test Products in a Real-Life Context The microbiome comprises a complex ecosystem of microorganisms that live together in a delicate balance, which is why it's best to test directly upon it directly. To fully understand the impact a product is having on the microbiome, in vivo is the only way. Collect Longitudinal Data With in vivo testing we can design your study around the extended use of a product over multiple time points. This allows us to review how a product is performing before and after usage, but also take into account its gradual impact on the microbiome. Measure Against a Control Group Measure a product against a control group that might have a different percentage of your active ingredient within its formulation or no active at all. This will allow for deeper insights into the impact of a formulation on microbial balance and diversity. 4 Sequencing Reports To Pick From Depending on your development stage and what you are interested in studying we offer qPCR, 16S, ITS, and Shotgun Metagenomics. With our qPCR Smart Probes™ we can go down to the strain level in our analysis. Personalize Your Microbiome Study! Unlike hair, the scalp is formed of a living community of microorganisms such as bacterial and fungal players that can influence the balance of the scalp microbiome, even the subtlest of imbalances can lead to issues such as dandruff, itching, and irritation, resulting in unwanted flaking. Smart Probe s ™ Our dedicated team of scientists have developed a method of evaluating microbes through our Smart Probes ™ . These refer to a panel of 20 key microbes we have specifically identified as having the most impact on scalp health. Over and above the taxonomic characterisation that 16S offers, which gives us a snapshot of all the genus present within a collected sample (Cutibacterium , Staphylococcus , etc.) our targeted approach takes it a step further, opening the lens to the species (C. acnes ), sub-species (C. acnes defendens ) and even strains within them. This is a crucial distinction as not all strains of a species behave similarly. We find that within these species there are strains associated with inflammation and strains that are commensal, and beneficial. Gold Standard Certification Sequential has developed the gold standard test for products designed to target the microbiome, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. ​ Using next-generation sequencing of the collection of micro-organisms found on the body, before and after product usage, Sequential investigates the microbial balance and diversity, and particular micro-organisms we know are important and play a role in a healthy microbiome. ​ We give you an in vivo certification that your product maintains the microbiome. And it’s not exclusive to skincare! We do this for haircare products, oral products, and vulva/vaginal microbiomes. Personalize Your Microbiome Study! Supplement Your Microbiome Study Recruitment Services Let us take care of the entire candidate recruitment process for you! View More Biophysical Assessments Increase your data on the use of your product by evaluating additional biophysical factors. View More Formulation Support Seek consultation advice for your formulation if you are re-formulating or developing a new product. View More FAQ What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations. Personal Skin Health Tracker - Sequential Skin - Skin age Test The skin health tracker Benefit of your personal Skin Health Tracker Download your personal Skin Health Tracker app to receive your microbiome test results and unlock personalized skincare tips. Results Skin Profile Receive your comprehensive skin microbiome sample results. Results Accessibility Access to your Skin Profile results in the palm of your hand. Results Unlock Our Expertise Learn skincare tips to help you with your own perceived skin traits. Results Discover Learn more about the skin microbiome through our Discover articles. What is Sequential's testing platform? Sequential has developed the gold standard test for microbiome-friendly products, in vivo (in, or on, humans). Finally, we can give some certainty about if a product is truly affecting the microbiome. We offer a complete end-to-end solution to support microbiome-friendly claims. From consultancy and study design to our proprietary microbiome testing kits. We analyse, interpret and report our findings to meet your needs. Why is it necessary to test the microbiome in vivo? At present, there are no regulations for microbiome-related formulas that brands and formulators can follow, however, it has been universally acknowledged that the in vivo method of conducting clinical studies is becoming critical and paramount to getting marketing claims through. When regulations are introduced, which may be imminent, the in vitro system will find itself lacking, resulting in limited claims and certifications that do not hold their value. This is why, we at Sequential strive to offer an in vivo approach, knowing full well that we want our client's claims to be significantly backed by scientific and quantifiable data. What type of sequencing technology does Sequential use for analysis? We offer four types of sequencing techniques including qPCR with our Smart Probes™, 16S, ITS and Shotgun Metagenomics. Using next-generation sequencing of the collection of microorganisms found on the body, during product usage, Sequential investigates the microbial diversity, and particular microorganisms we know are important and play a role in a healthy microbiome. Does Sequential offer claims certification for tested products? We provide our clients with a certification to claim “Maintains the Microbiome” subject to in vivo testing results which can be used in communication efforts. Once your product is tested with our qPCR Smart Probes™ and has shown favourable results in supporting the microbiome, we can certify your product with our Maintains the Microbiome certification seal. We have ensured that our seal and certification are backed by quantifiable data and scientifically significant markers. The aim is to ensure our clients feel confident in making their claims and can communicate the true benefit of their microbiome formulations. Unearth the secrets of your microbiome View All Research | Sequential The Skin Microbiome Review All Posts White Papers Skin Microbiome Scalp Microbiome Vaginal Microbiome Oral Microbiome Baby Microbiome 33 minutes ago Skin Microbiome Wound Wonders: Innovation in the Microbiome Space for Burn Healing In the UK, around 120,000 people visit A&E annually due to burn injuries, with 72% resulting in hypertrophic scarring, a type of raised... 6 days ago Skin Microbiome Is Swimming Wrecking Your Skin Microbiome? Swimming is a widely enjoyed physical activity that provides various health benefits, such as improved cardiovascular fitness, enhanced... Aug 21 Scalp Microbiome Exploring the Impact of The Scalp Microbiome on Alopecia Treatments: New Insights and Innovations The scalp microbiome plays a crucial yet often overlooked role in the development and treatment of alopecia. Studies have shed light on... Aug 16 Skin Microbiome Diabetes Dilemma: The Skin Microbiome’s Influence on Diabetic Skin and Wound Healing Diabetes mellitus is a chronic condition marked by elevated blood glucose levels due to abnormal insulin production or insulin... Aug 14 Is Micro-Botox Disrupting the Skin's Microbiome Balance? Micro-Botox is a specialised technique involving the injecting of diluted botulinum toxin into the skin. It is a frequently performed... Aug 9 Skin Microbiome Could Snail Mucin Be the Secret to a Thriving Skin Microbiome? Snail mucin is the secretion produced by various species of snails, and it has recently gained attention for its potential benefits in... Aug 9 Oral Microbiome Igniting Inquiry: Unravelling Smoking's Impact on the Oral Microbiome While the harmful effects of smoking on overall health are widely recognised, its impact on the oral microbiome is still not fully... Aug 2 Skin Microbiome Don't Sweat It: How Deodorant Disrupts Your Underarm Microbiome The underarm (axillary) microbiome plays a crucial role in body odour production. Although deodorants and fragranced cosmetic products... Aug 1 Skin Microbiome Mosquitoes vs. Microbes: Can Your Skin's Secret Agents Defend Against Malaria? Malaria remains one of the deadliest diseases of the last century, posing a significant global health challenge. Researchers are... Jul 22 Skin Microbiome The Microbial Mysteries of Sensitive Skin: Unveiling the Microbiome's Role Sensitive skin (SS), also known as cutaneous sensory syndrome, is characterised by abnormal hypersensitivity to various stimuli, leading... Jul 5 Scalp Microbiome Unlocking the Power of Rosemary Oil: Is This A Natural Solution for Scalp Health? Rosemary oil has become increasingly popular in the hair care cosmetics industry, praised for its potential to improve scalp health and... Jun 28 Skin Microbiome The Hidden Changes: How Does Ageing Transform Our Skin Microbiome? Although the ageing process is complex and individualised, research highlights the significant role of the skin microbiome in skin... Jun 25 White Papers Artificial Intelligence: Decoding the Microbiome or Complicating It? The skin microbiome, a complex ecosystem of bacteria, fungi, viruses, and other microorganisms living on our skin, plays a crucial role... Jun 21 Oral Microbiome More Than Just the Mouth: Therapeutic Insights Into the Oral Microbiome's Role in Alzheimer's Disease Alzheimer's disease (AD) is a progressive neurodegenerative condition characterised by memory loss, changes in personality and behaviour... Jun 19 Skin Microbiome Understanding the Gut-Skin Axis Both the gut and skin are colonised with distinct microbial communities and operate as crucial organs in the body. Jun 19 Skin Microbiome Understanding Skin Ageing Skin ageing is a natural and inevitable process caused by structural and functional changes in skin cells due to intrinsic and extrinsic fac Jun 19 Skin Microbiome Understanding Atopic Dermatitis Atopic dermatitis (AD), also known as atopic eczema, is a common chronic inflammatory skin condition that is characterised by inflamed, dry Jun 19 Skin Microbiome Acne & The Skin Microbiome? Acne is a well-known chronic inflammatory condition that impacts individuals of all age groups worldwide. Jun 19 Skin Microbiome Illuminating the Skin: The Influence of LED Masks on the Skin Microbiome In the world of skincare, light-emitting diode (LED) technology has emerged as a powerful tool, emitting specific wavelengths of light,... Jun 14 Scalp Microbiome Exploring the Intricacies of Scalp and Hair Microbiomes: Unveiling Host Factors and Industry Implications The scalp hair shaft microbiota is distinct from that of the scalp skin. Jun 14 Skin Microbiome What Role Does the Skin Microbiome Play in the Complex Process of Wound Healing? The interplay between skin wounds and the skin microbiome presents a captivating area of study. May 17 Scalp Microbiome Unveiling the Enigma of Fungal Acne: How Does the Skin Microbiome Cause Malassezia Folliculitis? Often colloquially termed "fungal acne," Malassezia folliculitis (MF) is an infection of the hair follicle triggered by yeasts belonging to May 17 Vaginal Microbiome Delving into Feminine Wellness: Redefining Intimate Care with the Vulvar Microbiome While our understanding of the microbial composition of the vulva is still evolving, it holds the potential to maintain overall genital heal May 17 Skin Microbiome How Does the Skin Microbiome Influence Rosacea? Unveiling the Microbial Puzzle Rosacea, a chronic inflammatory skin condition, involves complex interactions between the skin microbiota and host conditions. 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The Skin Microbiome Review All Posts White Papers Skin Microbiome Scalp Microbiome Vaginal Microbiome Oral Microbiome Baby Microbiome 33 minutes ago Skin Microbiome Wound Wonders: Innovation in the Microbiome Space for Burn Healing In the UK, around 120,000 people visit A&E annually due to burn injuries, with 72% resulting in hypertrophic scarring, a type of raised... 6 days ago Skin Microbiome Is Swimming Wrecking Your Skin Microbiome? Swimming is a widely enjoyed physical activity that provides various health benefits, such as improved cardiovascular fitness, enhanced... Aug 21 Scalp Microbiome Exploring the Impact of The Scalp Microbiome on Alopecia Treatments: New Insights and Innovations The scalp microbiome plays a crucial yet often overlooked role in the development and treatment of alopecia. Studies have shed light on... Aug 16 Skin Microbiome Diabetes Dilemma: The Skin Microbiome’s Influence on Diabetic Skin and Wound Healing Diabetes mellitus is a chronic condition marked by elevated blood glucose levels due to abnormal insulin production or insulin... Aug 14 Is Micro-Botox Disrupting the Skin's Microbiome Balance? Micro-Botox is a specialised technique involving the injecting of diluted botulinum toxin into the skin. It is a frequently performed... Aug 9 Skin Microbiome Could Snail Mucin Be the Secret to a Thriving Skin Microbiome? Snail mucin is the secretion produced by various species of snails, and it has recently gained attention for its potential benefits in... Aug 9 Oral Microbiome Igniting Inquiry: Unravelling Smoking's Impact on the Oral Microbiome While the harmful effects of smoking on overall health are widely recognised, its impact on the oral microbiome is still not fully... Aug 2 Skin Microbiome Don't Sweat It: How Deodorant Disrupts Your Underarm Microbiome The underarm (axillary) microbiome plays a crucial role in body odour production. Although deodorants and fragranced cosmetic products... Aug 1 Skin Microbiome Mosquitoes vs. Microbes: Can Your Skin's Secret Agents Defend Against Malaria? Malaria remains one of the deadliest diseases of the last century, posing a significant global health challenge. Researchers are... Jul 22 Skin Microbiome The Microbial Mysteries of Sensitive Skin: Unveiling the Microbiome's Role Sensitive skin (SS), also known as cutaneous sensory syndrome, is characterised by abnormal hypersensitivity to various stimuli, leading... Jul 5 Scalp Microbiome Unlocking the Power of Rosemary Oil: Is This A Natural Solution for Scalp Health? Rosemary oil has become increasingly popular in the hair care cosmetics industry, praised for its potential to improve scalp health and... Jun 28 Skin Microbiome The Hidden Changes: How Does Ageing Transform Our Skin Microbiome? Although the ageing process is complex and individualised, research highlights the significant role of the skin microbiome in skin... Jun 25 White Papers Artificial Intelligence: Decoding the Microbiome or Complicating It? The skin microbiome, a complex ecosystem of bacteria, fungi, viruses, and other microorganisms living on our skin, plays a crucial role... Jun 21 Oral Microbiome More Than Just the Mouth: Therapeutic Insights Into the Oral Microbiome's Role in Alzheimer's Disease Alzheimer's disease (AD) is a progressive neurodegenerative condition characterised by memory loss, changes in personality and behaviour... Jun 19 Skin Microbiome Understanding the Gut-Skin Axis Both the gut and skin are colonised with distinct microbial communities and operate as crucial organs in the body. Jun 19 Skin Microbiome Understanding Skin Ageing Skin ageing is a natural and inevitable process caused by structural and functional changes in skin cells due to intrinsic and extrinsic fac Jun 19 Skin Microbiome Understanding Atopic Dermatitis Atopic dermatitis (AD), also known as atopic eczema, is a common chronic inflammatory skin condition that is characterised by inflamed, dry Jun 19 Skin Microbiome Acne & The Skin Microbiome? Acne is a well-known chronic inflammatory condition that impacts individuals of all age groups worldwide. Jun 19 Skin Microbiome Illuminating the Skin: The Influence of LED Masks on the Skin Microbiome In the world of skincare, light-emitting diode (LED) technology has emerged as a powerful tool, emitting specific wavelengths of light,... Jun 14 Scalp Microbiome Exploring the Intricacies of Scalp and Hair Microbiomes: Unveiling Host Factors and Industry Implications The scalp hair shaft microbiota is distinct from that of the scalp skin. Jun 14 Skin Microbiome What Role Does the Skin Microbiome Play in the Complex Process of Wound Healing? The interplay between skin wounds and the skin microbiome presents a captivating area of study. May 17 Scalp Microbiome Unveiling the Enigma of Fungal Acne: How Does the Skin Microbiome Cause Malassezia Folliculitis? Often colloquially termed "fungal acne," Malassezia folliculitis (MF) is an infection of the hair follicle triggered by yeasts belonging to May 17 Vaginal Microbiome Delving into Feminine Wellness: Redefining Intimate Care with the Vulvar Microbiome While our understanding of the microbial composition of the vulva is still evolving, it holds the potential to maintain overall genital heal May 17 Skin Microbiome How Does the Skin Microbiome Influence Rosacea? Unveiling the Microbial Puzzle Rosacea, a chronic inflammatory skin condition, involves complex interactions between the skin microbiota and host conditions.