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Niacinamide is a naturally occurring form of vitamin B3 present in products such as meat, fish, and green vegetables. Consuming this vitamin either topically or orally can provide the skin with an assortment of benefits from strengthening the skin barrier, to balancing the microbiome, and ensuring healthy balance of sebum production!
What we know:
Topical application of niacinamide has been found to reduce the signs of ageing (Bissett et al., 2004)
It also has powerful photoprotective and anticarcinogenic effects, being able to reduce skin tumour incidence from 75 to 43% in UV irradiated mice models when applied topically, or from 68 to 28% when consumed orally (Damian 2010)
When applied to subjects with rosacea, a niacinamide-containing facial moisturiser was able to improve stratum corneum barrier function and hydration after 4 weeks, with significant improvements in rosacea symptoms like dryness, scaling, and inflammatory lesions reported over the course of the study (Draelos et al., 2005)
Niacinamide-based moisturisers are also able to lessen the sebum excretion rate, one study reporting a 21.8% reduction after just 4 weeks of using 2% niacinamide, something that has useful potential in treating acne-prone skin and certain microbes like Cutibacterium acnes responsible for exacerbating this condition (Draelos et al., 2006)
The skin microbiome has also been found to be supported by niacinamide, which sustains a healthy cutaneous microflora by enhancing the action of antimicrobial peptides that help regulate the growth of pathogens like Staphylococcus aureus associated with conditions like atopic dermatitis (Losasso et al., 2022)
Industry impact & potential:
Niacinamide-based skincare is a major industry in the cosmetic market, reaching $546.1 million market value in 2021 and expected to grow to $832.4 million by 2031 (Allied Market Research, 2022).
Versatile active, its bioavailability is one of the most attractive characteristics as a topical ingredient. Its water solubility makes this form of Vitamin B3 active within the viable skin cells to provide benefits.
As consumers continue to become well-versed in making informed decisions regarding their skin health, it’s crucial for companies to consider how those demands are influencing product development and purchasing behaviours.
Our solution:
Here at Sequential, we are able to test the effectiveness of niacinamide-containing formulations (both oral and/or topical!) on both physical skin parameters, and global skin microbiome effects using our Gold Standard invivo approach. Previously working with global leaders in the personal care industry to validate and improve their formulations, we carry the expertise to make sure your product meets industry standards and delivers the best quality skincare there is.
References:
Bissett DL, Miyamoto K, Sun P, Li J, Berge CA. Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin. Int J Cosmet Sci. 2004 Oct;26(5):231-8. doi: 10.1111/j.1467-2494.2004.00228.x. PMID: 18492135.
Damian DL. Photoprotective effects of nicotinamide. Photochem Photobiol Sci. 2010 Apr;9(4):578-85. doi: 10.1039/b9pp00146h. PMID: 20354654.
Draelos ZD, Ertel K, Berge C. Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea. Cutis. 2005 Aug;76(2):135-41. PMID: 16209160.
Draelos ZD, Matsubara A, Smiles K. The effect of 2% niacinamide on facial sebum production. J Cosmet Laser Ther. 2006 Jun;8(2):96-101. doi: 10.1080/14764170600717704. PMID: 16766489.
Losasso V, Agarwal K, Waskar M, Majumdar A, Crain J, Winn M, Hoptroff M. Small molecules enhance the potency of natural antimicrobial peptides. Biophys J. 2022 Feb 1;121(3):491-501. doi: 10.1016/j.bpj.2021.12.029. Epub 2021 Dec 24. PMID: 34954157; PMCID: PMC8822605.
"Niacinamide Market Size, Segments Analysis I Prediction - 2031." Allied Market Research, 2023. Allied Market Research Niacinamide Market Report.
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