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Skin microbiome transplantation is an emerging therapeutic approach designed to restore a healthy balance of microbial communities on the skin, especially in relation to various dermatological conditions. Recent research has underscored the crucial role of the skin microbiome in maintaining skin health and its contribution to the development of skin diseases like atopic dermatitis, psoriasis, and acne vulgaris. By transplanting healthy skin microbiota, it may be possible to reverse dysbiosis in microbial populations that can trigger inflammatory skin conditions.
What we know:
Transplantation can involve transferring whole skin microbiota from a healthy individual or using an artificial mixture of selected microorganisms (Junca et al., 2022).
The transplantation method is influenced by the interplay between donor microbiome composition, recipient microbiome composition, and transplant load, with certain combinations enhancing engraftment (Boxberger et al., 2021).
Studies have shown that transferring entire skin microbiomes between different body sites can replicate specific microbial effects, such as odour-causing bacteria could be transferred from the armpit to the forearm (Callewaert et al., 2021).
Transfer of microbiome swabs from the arm to the upper back, found greater diversity in the inner elbow compared to the back. Four arm-specific species persisted on the back after 24 hours, mainly from Gardnerella, Brachybacterium, and Actinomyces (Callewaert et al., 2021).
In a clinical study, siblings were enrolled, including one with strong body odour. The skin microbiome from the non-odorous sibling was successfully transferred, resulting in reduced body odour and a new microbial balance with more staphylococci and fewer corynebacteria (Callewaert et al., 2021).
Industry impact & potential:
Transferring live microorganisms from healthy donors to patients poses risks, necessitating pathogen screening standards (Junca et al., 2022).
Standardization of microbiome collection, preparation, and storage methods is essential for assessing transplantation efficacy (Junca et al., 2022).
Understanding microbiome interactions and pathofunctions will support personalized therapeutic strategies targeting specific skin microbiota functions (Junca et al., 2022).
Our solution:
Sequential is a company focused on skin microbiome testing, utilizing advanced sequencing technologies to analyze skin microbial communities. We offer valuable insights into the microbiome profiles of individuals skin, enabling the development of personalized treatment plans. By collaborating with dermatologists and researchers, we contribute significantly to the advancement of microbiome-based diagnostics and therapeutics.
Reference:
Boxberger, M., Cenizo, V., Cassir, N. Challenges in exploring and manipulating the
human skin microbiome. Microbiome 9, 125 (2021). https://doi.org/10.1186/s40168-021-01062-5
Callewaert C, Knödlseder N, Karoglan A, Güell M, Paetzold B. Skin microbiome
transplantation and manipulation: Current state of the art. Comput Struct Biotechnol J. 2021 Jan 4;19:624-631. doi: 10.1016/j.csbj.2021.01.001. PMID: 33510866; PMCID: PMC7806958.
Junca H, Pieper DH, Medina E. The emerging potential of microbiome transplantation on
human health interventions. Comput Struct Biotechnol J. 2022 Jan 19;20:615-627. doi: 10.1016/j.csbj.2022.01.009. PMID: 35140882; PMCID: PMC8801967.
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